Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD)

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Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD).

OBJECTIVE Interstitial lung disease (ILD) may be a characteristic, often serious, manifestation of mixed connective tissue disease (MCTD). In this retrospective study, the frequency and clinical picture of ILD were determined in patients with MCTD using two diagnostic tests: high-resolution computed tomography (HRCT) and inhaled aerosol clearance times of (99m)Tc-labelled diethylene-triamine pe...

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Vascular disease in mixed connective tissue disease (MCTD).

Sharp et al first described mixed connective tissue disease (MCTD)in 1972 as a distinct entity of connective tissue disease (1). MCTDis a disease entity characterized by overlap symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and polymyositis/dermatomyositis (PM/DM), as well as by the presence of antibody to U1RNRHowever, it has been suggested that rather than being reg...

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Exercise limitation in juvenile onset Mixed Connective Tissue Disease (MCTD)

Results VO2peak was significantly lower in patients with MCTD compared to the VO2peak of healthy subjects (z-score -1.9, p = 0.008). The strength of the proximal muscles (hip flexors, shoulder abductors, knee extensors) of the patients was significantly lower than the controls, whereas the strength of the distal muscles (dorsal flexors of the foot and grip strength) was rather similar. No clini...

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Interstitial lung disease evaluation: detecting connective tissue disease.

Interstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) and is often associated with significant morbidity and mortality. The evaluation of ILD in patients with CTD is complex because of the heterogeneity of the CTD spectrum, the various patterns and degrees of severity of ILD encountered, and because ILD can be identified at any point in time in these patie...

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Interstitial lung disease in connective tissue disorders.

Some of the most pressing challenges associated with interstitial lung disease (ILD) are how best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD)--disorders with potentially substantial morbidity and mortality. In this focused review, we address aspects of prognosis for CTD-ILD and what indices might predict outcome, together with lessons that can be learnt fro...

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2005

ISSN: 1462-0332,1462-0324

DOI: 10.1093/rheumatology/keh575